Dynamic Key Med(DKM)--- Active Compounds
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Research Areas：
Proteases
Apoptosis
Chromatin/Epigenetics
Metabolism
MAPK Signaling
Tyrosine Kinase
DNA Damage/DNA Repair
PI3K/Akt/mTOR
Microbiology & Virology
Ubiquitination/ Proteasome
JAK/STAT Signaling
TGF-β / Smad Signaling
Angiogenesis
GPCR/G protein
Endocrinology and Hormones
Immunology/Inflammation
Neuroscience
Membrane Transporter/Ion Channel
Others
Antibody-drug Conjugate/ADC Related
Antioxidants
Peptides
Default
Research Grade Biosimilar
ATPase
Cancer Biology
Cell Cycle/Checkpoint
Epigenetics
Infectious Disease
Natural Products
Active Pharmaceutical Ingredients
PROTAC
Stem Cell
Signaling Pathways：
HIF
BTK
JAK
ACP-196 （CAS#1420477-60-6 Cat#D915453）
CAS#：
1420477-60-6
Formula：
C₂₆H₂₃N₇O₂
Molecular Weight：
465.51
Solubility：
≥ 46.6mg/mL in DMSO with gentle warming
Biological Target：
irreversible BTK inhibitor
Storage：
Store at -20°C
BTK
$64.00
万
RN486 （CAS#1242156-23-5 Cat#D911230）
CAS#：
1242156-23-5
Formula：
C₃₅H₃₅FN₆O₃
Molecular Weight：
606.6900000000001
Solubility：
≥ 30.35mg/mL in DMSO with gentle warming
Biological Target：
Btk inhibitor,potent and selective
Storage：
Store at -20°C
BTK
$121.00
万
AVL-292 （CAS#1202757-89-8 Cat#D913562）
CAS#：
1202757-89-8
Formula：
C₂₂H₂₂FN₅O₃
Molecular Weight：
423.44
Solubility：
≥ 21.15 mg/mL in DMSO, ≥ 4.9 mg/mL in EtOH with ultrasonic and warming
Biological Target：
Btk inhibitor
Storage：
Store at -20°C
BTK
$104.00
万
GDC-0834 （CAS#1133432-50-4 Cat#D911995）
CAS#：
1133432-50-4
Formula：
C₃₃H₃₆N₆O₃S
Molecular Weight：
596.74
Solubility：
Soluble in DMSO
Biological Target：
potent and selective BTK inhibitor
Storage：
Store at -20° C
BTK
$341.00
万
CNX-774 （CAS#1202759-32-7 Cat#D913439）
CAS#：
1202759-32-7
Formula：
C₂₆H₂₂FN₇O₃
Molecular Weight：
499.5
Solubility：
DMF: 30 mg/ml,DMF:PBS(pH 7.2)(1:6): 0.14 mg/ml,DMSO: 25 mg/ml
Biological Target：
BTK inhibitor, orally active, irreversible and selective
Storage：
Store at -20° C
BTK
$201.00
万
Ruxolitinib (INCB018424) （CAS#941678-49-5 Cat#D914191）
CAS#：
941678-49-5
Formula：
C₁₇H₁₈N₆
Molecular Weight：
306.37
Solubility：
≥ 15.32mg/mL in DMSO
Biological Target：
A JAK inhibitor
Storage：
Store at -20°C
JAK
$63.00
万
(-)-Terreic acid （CAS#121-40-4 Cat#D912164）
CAS#：
121-40-4
Formula：
C₇H₆O₄
Molecular Weight：
154.12
Solubility：
DMF: soluble,DMSO: 10 mg/ml,Ethanol: soluble,Methanol: soluble,Water: 5 mg/ml
Biological Target：
Bruton's tyrosine kinase (BTK) inhibitor
Storage：
Store at -20°C
BTK
$105.00
万
Ruxolitinib phosphate （CAS#1092939-17-7 Cat#D805242）
Cat#：
D805242
Synonym：
INCB018424; INCB 018424; INCB-018424; INC424; INC-424; INC424; INCB18424; INCB 18424; INCB-18424; trade name: Jakafi and Jakavi
CAS#：
1092939-17-7
Formula：
C₁₇H₂₁N₆O₄P
Molecular Weight：
404.36
Solubility：
≥ 20.2 mg/mL in DMSO, ≥ 6.92 mg/mL in EtOH with ultrasonic and warming, ≥ 8.03 mg/mL in H2O with ultrasonic and warming
Biological Target：
JAK1/JAK2 inhibitor,Ruxolitinib Phosphate (INCB018424, INC424) is the phosphate salt form of Ruxolitinib.
Storage：
Store at -20°C
JAK
$44.00
万
GDC-0853 （CAS#1434048-34-6 Cat#D919162）
CAS#：
1434048-34-6
Formula：
C₃₇H₄₄N₈O₄
Molecular Weight：
664.8
Solubility：
DMSO : ≥ 23 mg/mL (34.60 mM)
Biological Target：
GDC-0853 is a potent, selective, and noncovalent bruton's tyrosine kinase (Btk) inhibitor with a Ki of 0.91 nM.
Storage：
Store at -20°C
BTK
$84.00
万
Molidustat (BAY85-3934) （CAS#1154028-82-6 Cat#D910046）
CAS#：
1154028-82-6
Formula：
C₁₃H₁₄N₈O₂
Molecular Weight：
314.3
Solubility：
≥ 5.68mg/mL in DMF
Biological Target：
Novel HIF-PH inhibitor
Storage：
Store at -20°C
HIF
$96.00
万
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