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Research Areas：
Proteases
Apoptosis
Chromatin/Epigenetics
Metabolism
MAPK Signaling
Tyrosine Kinase
DNA Damage/DNA Repair
PI3K/Akt/mTOR
Microbiology & Virology
Ubiquitination/ Proteasome
JAK/STAT Signaling
TGF-β / Smad Signaling
Angiogenesis
GPCR/G protein
Endocrinology and Hormones
Immunology/Inflammation
Neuroscience
Membrane Transporter/Ion Channel
Others
Antibody-drug Conjugate/ADC Related
Antioxidants
Peptides
Default
Research Grade Biosimilar
ATPase
Cancer Biology
Cell Cycle/Checkpoint
Epigenetics
Infectious Disease
Natural Products
Active Pharmaceutical Ingredients
PROTAC
Stem Cell
Signaling Pathways：
PKC
TGF-β Receptor
ROCK
(S)-Glycyl-H-1152 (hydrochloride) （CAS#913844-45-8 Cat#D941737）
CAS#：
913844-45-8
Formula：
C₁₈H₂₄N₄O₃S•₂HCl
Molecular Weight：
449.4
Solubility：
DMF: 5 mg/ml,DMSO: 10 mg/ml,Ethanol: 2 mg/ml,PBS (pH 7.2): 10 mg/ml
Biological Target：
Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability.
Storage：
Store at -20°C
ROCK
$142.00
万
Bisindolylmaleimide XI (hydrochloride) （CAS#145333-02-4 Cat#D918716）
CAS#：
145333-02-4
Formula：
C₂₈H₂₈N₄O₂.HCl
Molecular Weight：
489
Solubility：
DMSO: Soluble,Methanol: Soluble
Biological Target：
Bisindolylmaleimide XI (BIM XI) is a selective, cell-permeable protein kinase C (PKC) inhibitor that displays 10-fold greater selectivity for PKCα (IC50 = 9 nM) and 4-fold greater selectivity for PKCβI (IC50 = 28 nM) over Ca2+-independent PKCε (IC50 = 108 nM).
Storage：
Store at -20°C
PKC
$133.00
万
SB 772077B dihydrochloride （CAS#607373-46-6 Cat#D915170）
CAS#：
607373-46-6
Formula：
C₁₅H₁₈N₈O₂.₂HCl
Molecular Weight：
415.28
Solubility：
<41.53mg/ml in H2O; <41.53mg/ml in DMSO
Biological Target：
Rho-kinase (ROCK) inhibitor
Storage：
Desiccate at RT
ROCK
$495.00
万
Bryostatin 1 （CAS#83314-01-6 Cat#D917670）
CAS#：
83314-01-6
Formula：
C₄₇H₆₈O₁₇
Molecular Weight：
905.04
Solubility：
Soluble in DMSO and in ethanol
Biological Target：
PKC activator
Storage：
Store at -20°C
PKC
$311.00
万
Bisindolylmaleimide I (hydrochloride) （CAS#176504-36-2 Cat#D918725）
CAS#：
176504-36-2
Formula：
C₂₅H₂₄N₄O₂.HCl
Molecular Weight：
449
Solubility：
DMF: 10 mg/mL,DMSO: 16 mg/mL,DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL
Biological Target：
Bisindolylmaleimide I (BIM I) is a highly selective, cell-permeable, and reversible PKC inhibitor (Ki = 14 nM) that is structurally similar to the poorly selective PKC inhibitor staurosporine .
Storage：
Store at -20°C
PKC
$49.00
万
Belumosudil (KD025),SLx-2119 （CAS#911417-87-3 Cat#D912827）
Synonym：
SLx-2119; SLx2119; SLx 2119; KD-025; KD025; KD 025
Purity：
>99%
CAS#：
911417-87-3
Formula：
C₂₆H₂₄N₆O₂
Molecular Weight：
452.51
Solubility：
≥ 22.65 mg/mL in DMSO, ≥ 26.4 mg/mL in EtOH with ultrasonic and warming
Biological Target：
ROCK2:105 nM (IC50); ROCK1:24 μM (IC50)
Storage：
Store at -20°C
ROCK
$114.00
万
Rottlerin （CAS#1982/8/6 Cat#D910820）
CAS#：
08-06-82
Formula：
C₃₀H₂₈O₈
Molecular Weight：
516.55
Solubility：
100mM in DMSO
Biological Target：
PKC inhibitor
Storage：
Store at -20°C
PKC
$92.00
万
ITD 1 （CAS#1099644-42-4 Cat#D912108）
CAS#：
1099644-42-4
Formula：
C₂₉H₃₂N₆O₄S
Molecular Weight：
560.67
Solubility：
≥ 28.05mg/mL in DMSO
Biological Target：
First selective TGFβ inhibitor
Storage：
Store at -20°C
TGF-β Receptor
$78.00
万
Dequalinium Chloride （CAS#522-51-0 Cat#D916354）
CAS#：
522-51-0
Formula：
C₃₀H₄₀N₄.₂Cl
Molecular Weight：
527.5700000000001
Solubility：
<5.28 mg/mL in DMSO
Biological Target：
anti-tumor agent and PKC inhibitor
Storage：
Store at -20°C
PKC
$49.00
万
LX7101 (hydrochloride) （Cat#D944094）
Formula：
C₂₃H₂₉N₇O₃•HCl
Molecular Weight：
488
Solubility：
DMF: 3 mg/ml,DMSO: 3 mg/ml,PBS (pH 7.2): 5 mg/ml
Biological Target：
LX7101 is a potent inhibitor of LIM kinase (LIMK) 1 and 2 and Rho-associated kinase 1 (ROCK-1) and ROCK-2 with IC50 values of 32, 4.3, 69, and 32 nM, respectively.
Storage：
Store at -20°C
ROCK
$85.00
万
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