Dynamic Key Med(DKM)--- Active Compounds
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Research Areas:
Proteases
Apoptosis
Chromatin/Epigenetics
Metabolism
MAPK Signaling
Tyrosine Kinase
DNA Damage/DNA Repair
PI3K/Akt/mTOR
Microbiology & Virology
Ubiquitination/ Proteasome
JAK/STAT Signaling
TGF-β / Smad Signaling
Angiogenesis
GPCR/G protein
Endocrinology and Hormones
Immunology/Inflammation
Neuroscience
Membrane Transporter/Ion Channel
Others
Antibody-drug Conjugate/ADC Related
Antioxidants
Peptides
Default
Research Grade Biosimilar
ATPase
Cancer Biology
Cell Cycle/Checkpoint
Epigenetics
Infectious Disease
Natural Products
Active Pharmaceutical Ingredients
PROTAC
Stem Cell
Signaling Pathways:
Telomerase
Nucleoside Antimetabolite/Analogue
PARP
DNA/RNA Synthesis
HDAC
Checkpoint Kinase (Chk)
CDK
DNA Methyltransferase
Deubiquitinase
(±)-BAY-1251152 (CAS#1610358-53-6 Cat#D933107)
CAS#:
1610358-53-6
Formula:
C₁₉H₁₈F₂N₄O₂S
Molecular Weight:
404.43
Solubility:
DMSO : 50 mg/mL (123.63 mM);H2O : < 0.1 mg/mL (insoluble)
Storage:
Store at -20°C
CDK
$162.00
万
CDK4/6-IN-4 (CAS#2138499-06-4 Cat#D938749)
CAS#:
2138499-06-4
Formula:
C₂₇H₃₂F₂N₈O
Molecular Weight:
522.59
Solubility:
DMSO: 5 mg/mL (9.57 mM)
Storage:
Store at -20°C
CDK
$135.00
万
Panobinostat (LBH589) (CAS#404950-80-7 Cat#D912257)
CAS#:
404950-80-7
Formula:
C₂₁H₂₃N₃O₂
Molecular Weight:
349.43
Solubility:
≥ 17.47mg/mL in DMSO
Biological Target:
HDAC inhibitor
Storage:
Store at -20°C
HDAC
$58.00
万
AZD2461 (CAS#1174043-16-3 Cat#D917965)
CAS#:
1174043-16-3
Formula:
C₂₂H₂₂FN₃O₃
Molecular Weight:
395.43
Solubility:
≥ 16.35 mg/mL in DMSO, ≥ 45.2 mg/mL in EtOH with ultrasonic
Biological Target:
Novel PARP inhibitor
Storage:
Store at -20°C
PARP
$67.00
万
ME0328 (CAS#1445251-22-8 Cat#D913419)
CAS#:
1445251-22-8
Formula:
C₁₉H₁₉N₃O₂
Molecular Weight:
321.37
Solubility:
≥ 71.4mg/mL in DMSO
Biological Target:
PARP inhibitor,potent and selective
Storage:
Store at -20° C
PARP
$60.00
万
BMN 673 (CAS#1207456-01-6 Cat#D915932)
CAS#:
1207456-01-6
Formula:
C₁₉H₁₄F₂N₆O
Molecular Weight:
380.35
Solubility:
≥ 19.0 mg/mL in DMSO, ≥ 14.2 mg/mL in EtOH with ultrasonic and warming
Biological Target:
Potent PARP inhibitor
Storage:
Store at -20°C
PARP
$90.00
万
CDKI-73 (CAS#1421693-22-2 Cat#D919096)
CAS#:
1421693-22-2
Formula:
C₁₅H₁₅FN₆O₂S₂
Molecular Weight:
394.45
Solubility:
DMSO : ≥ 52 mg/mL (131.83 mM);H2O : < 0.1 mg/mL (insoluble)
Biological Target:
CDKI-73 is a potent CDK9 inhibitor with Ki of 4 nM; shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM).
Storage:
Store at -20°C
CDK
$200.00
万
Droxinostat (CAS#99873-43-5 Cat#D913706)
CAS#:
99873-43-5
Formula:
C₁₁H₁₄ClNO₃
Molecular Weight:
243.69
Solubility:
≥ 11.35 mg/mL in DMSO, ≥ 102.8 mg/mL in EtOH
Biological Target:
Selective HDAC inhibitor
Storage:
Store at -20°C
HDAC
$43.00
万
AZD4573 (CAS#2057509-72-3 Cat#D932717)
CAS#:
2057509-72-3
Formula:
C₂₂H₂₈ClN₅O₂
Molecular Weight:
429.94
Solubility:
DMSO : ≥ 125 mg/mL (290.74 mM)
Storage:
Store at -20°C
CDK
$424.00
万
AZD7762 (CAS#860352-01-8 Cat#D910546)
CAS#:
860352-01-8
Formula:
C₁₇H₁₉FN₄O₂S
Molecular Weight:
362.42
Solubility:
≥ 18.1mg/mL in DMSO
Biological Target:
Checkpoint kinase inhibitor,ATP competitive
Storage:
Store at -20°C
Checkpoint Kinase (Chk)
$67.00
万
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