Dynamic Key Med(DKM)--- Active Compounds
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Research Areas：
Proteases
Apoptosis
Chromatin/Epigenetics
Metabolism
MAPK Signaling
Tyrosine Kinase
DNA Damage/DNA Repair
PI3K/Akt/mTOR
Microbiology & Virology
Ubiquitination/ Proteasome
JAK/STAT Signaling
TGF-β / Smad Signaling
Angiogenesis
GPCR/G protein
Endocrinology and Hormones
Immunology/Inflammation
Neuroscience
Membrane Transporter/Ion Channel
Others
Antibody-drug Conjugate/ADC Related
Antioxidants
Peptides
Default
Research Grade Biosimilar
ATPase
Cancer Biology
Cell Cycle/Checkpoint
Epigenetics
Infectious Disease
Natural Products
Active Pharmaceutical Ingredients
PROTAC
Stem Cell
Signaling Pathways：
JNK
cAMP
MEK1/2
PKA
MEK
P38
Raf
ERK
IQ 3 （CAS#312538-03-7 Cat#D912674）
CAS#：
312538-03-7
Formula：
C₂₀H₁₁N₃O₃
Molecular Weight：
341.32
Solubility：
<6.83mg/ml in DMSO
Biological Target：
Selective JNK3 inhibitor
Storage：
Store at -20°C
JNK
$366.00
万
PD98059 （CAS#167869-21-8 Cat#D912819）
CAS#：
167869-21-8
Formula：
C₁₆H₁₃NO₃
Molecular Weight：
267.28
Solubility：
≥ 40.23 mg/mL in DMSO
Biological Target：
MEK inhibitor,selective and reversible
Storage：
4°C, protect from light
MEK
$47.00
万
(S)-p38 MAPK Inhibitor III （CAS#581098-48-8 Cat#D941740）
CAS#：
581098-48-8
Formula：
C₂₃H₂₁FN₄S
Molecular Weight：
404.5
Solubility：
DMF: 20 mg/mL,DMSO: 12 mg/mL,Ethanol: 30 mg/mL,Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/mL
Biological Target：
(S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 μM in vitro).
Storage：
Store at -20°C
P38
$104.00
万
JNK-IN-8 （CAS#1410880-22-6 Cat#D913841）
CAS#：
1410880-22-6
Formula：
C₂₉H₂₉N₇O₂
Molecular Weight：
507.59
Solubility：
≥ 25.4 mg/mL in DMSO, ≥ 9.24 mg/mL in EtOH with ultrasonic and warming
Biological Target：
JNK inhibitor, selective and irreversible
Storage：
Store at -20°C
JNK
$105.00
万
Dibutyryl-cAMP, sodium salt （ Cat#D912824 ,CAS#16980-89-5）
CAS#：
16980-89-5
Formula：
C₁₈H₂₃N₅NaO₈P
Molecular Weight：
491.37
Solubility：
≥ 49.1mg/mL in H2O
Biological Target：
Cell-permeable cAMP analog that activates cAMP-dependent protein kinases
Storage：
Store at -20°C
cAMP
$83.00
万
PKI (14-22) amide (myristoylated) (trifluoroacetate salt) （Cat#D949265）
CAS#：
N/A
Formula：
C₅₃H₁₀₀N₂₀O₁₂·XCF₃COOH
Molecular Weight：
1209.5
Solubility：
DMSO: 1 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
Biological Target：
A PKA inhibitor
Storage：
-20°C
PKA
$168.00
万
VX-11e （CAS#896720-20-0 Cat#D913115）
CAS#：
896720-20-0
Formula：
C₂₄H₂₀Cl₂FN₅O₂
Molecular Weight：
500.35
Solubility：
≥ 25 mg/mL in DMSO, ≥ 12.65 mg/mL in EtOH with ultrasonic
Biological Target：
ERK inhibitor
Storage：
Store at -20°C
ERK
$89.00
万
PLX-4720 （CAS#918505-84-7 Cat#D914732）
CAS#：
918505-84-7
Formula：
C₁₇H₁₄ClF₂N₃O₃S
Molecular Weight：
413.83
Solubility：
≥ 20.69mg/mL in DMSO
Biological Target：
BRAF kinase inhibitor
Storage：
Store at 4°C
Raf
$75.00
万
JX 401 （CAS#349087-34-9 Cat#D913116）
CAS#：
349087-34-9
Formula：
C₂₁H₂₅NO₂S
Molecular Weight：
355.49
Solubility：
DMF: 20 mg/ml,DMF:PBS (pH 7.2) (1:5): 0.1 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml
Biological Target：
p38α inhibitor
Storage：
Store at RT
P38
$88.00
万
JNK-IN-7 （CAS#1408064-71-0 Cat#D915028）
CAS#：
1408064-71-0
Formula：
C₂₈H₂₇N₇O₂
Molecular Weight：
493.56
Solubility：
≥ 24.7 mg/mL in DMSO
Biological Target：
Selective JNK inhibitor
Storage：
Store at -20°C
JNK
$252.00
万
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